Public Health Foundation of India

Professor Dorairaj Prabhakaran, educated at Bangalore Medical College (MBBS), the All India Institute of Medical Sciences (MD: Internal Medicine and DM: Cardiology) and McMaster University Canada MSc: Health Research Methodology), is an eminent cardiologist, epidemiologist and academician of global repute. He moved beyond the conventional world of clinical cardiology to advance science in the prevention of heart diseases and diabetes in India so that his work could benefit millions of people in this country.

He established  large population cohorts  in India which have provided major insights in diverse domains, ranging from epidemiology, biomarkers, role of nutrition, on  heart diseases and diabetes. Evaluation of task shifting and mobile‐phone based solutions for providing personalized patient management solutions, and Yoga-care in cardiac rehabilitation (both of which were selected for the prestigious late breaking presentation at the American Heart Association meeting in 2018), are two best  exemplars of low cost, context specific solutions to enhance quality of therapeutic and preventive care for chronic diseases in India. A low cost worksite wellness program designed by his team with this philosophy was applauded by the 2008 World Economic Forum report, as one of the best worksite programs.

Prof Prabhakaran’s contribution to capacity building in chronic disease health research and training is exemplary. He was the founding Director of the Centre of Excellence in Cardia‐ metabolic Risk Reduction in South Asia, one of the 11 centres worldwide supported under the Global Health Initiative of National Institutes of Health (NIH) of USA. This centre has now transformed into an international partnership namely ‘Centre for Control of Chronic Conditions (CCCC)’ between four world‐class institutions: the All India Institute of Medical Sciences, Emory University, LSHTM and PHFI. He is an exceptional mentor of doctoral, post‐doctoral and physician scientists nationally and internationally, many of whom have become leaders in heart disease research. Prof. Prabhakaran has by far, more than 500 publications in scientific journals such as the New England Journal of Medicine, The Lancet, Circulation, British Medical Journal, Nature, JAMA, etc. and has an H‐Index of 83. He was the lead editor of  a major two volume text book of Cardiology which has been well received. He has been listed as the topmost researcher in Medicine in India terms of publications for the years 2009-2014 by Scopus and Department of Science & Technology, Government of India.

Prof Prabhakaran’s work has had large impact on science, health care and policy. Under his editorial leadership The World Bank published Cardiovascular Disease volume of the latest Disease Control Priorities Project. This volume estimates cost effectiveness of available interventions and provides a summary to policy makers across the world to   prioritize their investments.

His exceptional contributions spanning  Science, Medicine and Public Health has catapulted  the field of Preventive Cardiology in India and in the developing world.

Current Positions

• Distinguished Professor of Public Health
• Executive Director, Centre for Chronic Disease Control (CCDC) and Head, WHO Collaborating Centre for Surveillance, Capacity Building and Translational Research in Cardio-metabolic Diseases for the South-East Asia Region (WHOCC No. IND-124)
• Director of the Centre of excellence in Clinical Research at Centre for Chronic Disease Control, recognized by the Department of Biotechnology, Government of India
• Professor, Epidemiology, Public Health Foundation of India
• Professor, NCD epidemiology, London School of Hygiene and Tropical Medicine, London, UK
• Adjunct Professor, Rollins School of Public Health, Emory University, U.S.A

 Other Positions

• Director and Principal Investigator, NHLBI (USA) CARRS (Centre for cArdiometabolic Risk Reduction In South Asia) Centre of Excellence, PHFI, New Delhi ( 2009-2014)
• International Program Director, Fogarty International Centre at the PHFI, New Delhi (2009-2014); http://www.fogartyscholars.org
• Former Additional Professor, Department of Cardiology, CT Centre, All India Institute of Medical Sciences (AIIMS), New Delhi till October 2007
• Consultant/Technical Advisor to WHO (2005-2009): Prevention and Control of Cardiovascular/ Non-Communicable Diseases
• Technical Expert and Member, Scientific Advisory Committee on Non-Communicable Diseases, Indian Council of Medical Research (2004-till date)
• Co-Chair Scientific Advisory Committee on Non-Communicable Diseases, Indian Council of Medical Research (2014-till date)
• Technical advisor to the Ministry of Health, Government of India on developing the national cardiovascular disease and diabetic control programme (till 2007).
• Special Invitee to the Steering committee of the National Cardiovascular and diabetes Prevention Programme, of the Ministry of Health, Government of India (2008)
• Member, Capacity building subcommittee of the Steering committee of the National Cardiovascular and diabetes Prevention Programme, of the Ministry of Health, Government of India (2008)
• Member, Scientific Advisory Committee, Health Impact Fund
• Co-Chair, Scientific Committee of the World Congress of Cardiology, Melbourne, 2014
• Reviewer for National Medical Journal of India, Hypertension, International Journal of Cardiology, Open Medicine, Atherosclerosis, Circulation, PLoS Medicine, Lancet etc.
• Regional Policy Note Consultant for the World Bank in developing policy options for non-communicable diseases in Nepal and India.
• Consultant, World Bank for developing NCD component for the Karnataka Health System Development and Reforms Project
• Population Health Research Institute International Fellow, McMaster University, Hamilton, ON, Canada
• Associate Editor, Journal of Epidemiology and Community Health (JECH) 2008-2011
• Member, Executive Council, World Hypertension League
• Member Research Committee, Cardiology Society of India.
• Chairperson, Expert group on Salt, Sugar & Fat in Food Products in India constituted by Food Safety and Standards Authority of India (Standards Division) to develop guidelines for these foods (2016)
• John L. Locke Visiting Professor, University of Washington, October 2017
• Member, Executive Council and Chair of the South and West Asia Regional Advisory Group, International Society of Hypertension (ISH)
• Chair, Executive Council of the International Society of Cardiovascular Epidemiology and Prevention (ISCEP)
• Chairman , Science Committee, World Heart Federation
• Member, Advisory Board , Nature Reviews Cardiology

Copy right: Holds Copyright along with 3 other colleagues for a clinical decision support software – CARDIOMETCARE-m (No: L-61376/2015) – developed for the use of healthcare professionals for the management of hypertension and diabetes

Academic Qualifications

• MBBS, from Bangalore Medical College in 1985 with an overall percentage of 66% (first division) and was awarded distinction in Pharmacology.
• MD (Medicine), All India Institute of Medical Sciences, Delhi, 1990
• DM (Cardiology), All India Institute of Medical Sciences, Delhi, 1993
• MSc (Health Research Methodology), McMaster University, 2006

 Trainings/ Examinations

• Passed the USMLE examination held in September 93, with scores of 84 & 87 in part I & part II respectively
• Fellow of the 28th day International Teaching Seminar on Cardiovascular Epidemiology & Prevention of Cardiovascular Disease, under the ISFC, held at Munich from 20.8.95 to 1.9.95.
• Research fellowship at McMaster university from July 2002 to July 2004
• Attended the summer epidemiology course at Johns Hopkins University, Baltimore USA, to train in genetic epidemiology.

Awards (Personal)

• Listed as the topmost researcher in Medicine in India terms of publications for the years 2009-2014 by Scopus and Department of Science & Technology, Government of India.
• Hari and Madhu Varshney Visiting Professor at Simon Fraser University , Canada, 2020
• DL Shah Quality Champion Award (2018) by Quality Council of India
• BMJ South Asia Awards: Finalist Research Paper of the Year ( 2018)
• Uma Rani Banarjea Oration Award at the 68th Annual Cardiological Society of Indiameet at Kochi 2016
• 2nd Runner up award in Poster Presentation for Capacity Building in Health Care at FICCI Heal 2015 (FICCI is a large Indian Chamber of Commerce and this is a leadership award)
• Fellow, National Academy of Sciences, India, 2011
• Fellow of the Royal College of Physicians (FRCP), London, UK, 2011
• KK Datey Oration Award at the 61st Annual Cardiological Society of India meet at Kochi 2009
• 4th MDRF-UAB Oration Award bestowed by the Scientific Committee of the Madras Diabetes Research Foundation, Chennai for the outstanding scientist and researcher of 2009
• WCCPGC-2008 “Distinguished Service Award” bestowed upon by Bharat Ratna His Excellency Dr. A.P.J. Abdul Kalam (Former President of India) and Prof. Navin C. Nanda. USA
• P.S. Rao Gold Medal oration bestowed by the Andhra Pradesh Cardiological Society of India APCSI – 2007 held in Tirupati, Andhra Pradesh

Awards (Group)

• The Federation of Indian Chambers of Commerce and Industry (FICCI)- Healthcare Excellence Awards 2018 (10th Edition) for Skill Development for capacity building initiative to train primary care physicians in India in Chronic Diseases.
• Confederation of Indian Industry (CII)Sixth National Excellence Practice competition 2018 for Best NGO/Education skill building of primary care physicians in Chronic Diseases in India.
• DL Shah Platinum award (2017): Commendation Certificate and Award presented by the Quality Council of India for Excellence in skill building of primary care physicians in Chronic Diseases in India.
• PHD Chambers award for Excellence in Skill Development 2015
• FICCI Health Care Excellence award 2015 in skill development category during FICCI Heal 2015.
• ASSOCHAM commendation certificate and award under category of skill development as BEST NGO in Skill development 2015-16
• Diabetes Excellence award for community service 2016 by Apollo Sugar Clinics
• Finalist in the BMJ India award for Excellence in Medical education 2014

Special Interests

Clinical Cardiology and Cardiovascular Epidemiology 

Special Assignment

Cardiologist to Prime Minister of India from Oct.1994 till May 1996.

Personal Physician to Prime Minister of India during the periods 17-12-96 to 21-5-1997. This entailed both clinical and administrative duties.

Personal note on major contributions to science

During my training in Cardiology , at the Department of Cardiology, I was intrigued by the lower age of onset of CVD among Indians and became keen to  explore the mechanistic causes and the potential of preventive and low cost therapeutic solutions to combat this huge public health challenge. Two large epidemiological studies in my early career in the 90’s, highlighted the stark contrast in the dynamics of CVD and its risk factors in urban (Delhi) and rural (Haryana) and the unique epidemiology of CVD risk factors in  industrial populations. The two major papers emanating from these studies have been cited extensively. Subsequently I participated in or led several major international and national research studies including the INTERHEART Study and its precursor, the ICMR funded case -control study of acute myocardial infarction. These two landmark studies unravelled and identified the commonly-cited risk factors for acute myocardial infarction in the South Asians. Subsequently I have  participated in a number of analyses and publications that came from this study, and in particular, development of the INTERHEART Risk Score.

I have been an active investigator  of the New Delhi Birth Cohort that unravelled the crucial  role of life course approach in determining adult onset CVD and risk factors in the Indian population. Recognizing the importance of large population-based cohorts for understanding the complex play of social, economic, genetic, and environmental factors in shaping CVD dynamics in diverse population groups India, I have  led the design and conduct of the CARRS cohort (in the metropolis Delhi and Chennai – with funding from NIH), UDAY Cohort  (in the intermediate cities of Sonipat and Vishakhapatnam) and the Solan Cohort (in the rural populace of Himachal Pradesh). These cohorts are  well phenotyped and have been able to provide several mechanistic insights into the high propensity for cardiovascular disease and diabetes in South Asians. For example, the CARRS cohort is currently studying the role of air pollution in increasing the longitudinal risk of CVD in Delhi and Chennai with funding from the prestigious Geo-Health Program of the Fogarty international Centre of NIH. Thus, two decades of above described work has provided major insights into the epidemiology and mechanisms of  CVD. Recognizing my contribution, the global burden of disease group from the University of Washington invited me  to lead the State Level Disease Burden Study in India – on behalf of the Indian Council of Medical Research (ICMR), the Public Health Foundation of India (PHFI), Institute for Health Metrics and Evaluation (IHME) – which was published in Lancet Global Health last year.

Exploring Practice patterns and designing interventions to improve quality of care

I have  been actively involved in several national and international registries and quality improvement programs. These include  the OASIS, CREATE, DEMAT, KERALA ACS and the INTERCHF registries. These registries provided information on the prevailing patterns of treatment of ACS and heart failure and their relationship to in-hospital intermediate and long-term outcomes. In addition, it provided information on barriers, health beliefs and prescription patterns that needed improvements. Using the learnings from these registries I collaboratively devised and tested several innovative models such as:

• Quality improvement for improving secondary prevention among ACS patients
• Polypill strategy to improving compliance and adherence to medications among patients with high CVD risk
• YogaCare model for incorporating the practice of Cardiac rehabilitation in India

Translation Trials involving task shifting and mHealth in primary prevention of CVD

I have led and developed several projects in translation research that evaluate the role of physician assistants/nurses/community health workers and m-health (“mobile” health) programs to prevent and manage hypertension, diabetes and cardiovascular diseases in several settings (community, primary, secondary and tertiary care settings) and states of India. In addition, he developed and led a simple and low cost comprehensive cardiovascular risk reduction programme at 6 large industrial worksites in India. This intervention has been cited as an example of a good worksite  programme  for  evaluation  in  other  settings  by  the  World  Heart  Federation/  World Economic Forum meeting in Davos in 2008 (http://www.world-heart-federation.org/?id=2391) and by the US Institute of Medicine  (Promoting  Cardiovascular Health  in Developing  Countries:  A critical  challenge  to Achieve Global  Health  (2010);  National  Academics Press.  PP:  255, 270).

These “real-life” studies have enormous impact on informing what is truly possible in real-world settings. Some of these trials have been scaled up.

Contributions to Capacity building

I have been  an active  mentor of doctoral, post‐doctoral and physician scientists nationally and internationally. I  have  been supported by three major NIH grants ( the Fogarty scholars and fellows program, a D43 grant for interdisciplinary research training across the life span and the PH leader program) through the Fogarty International Centre  to conduct these programs. Many of the trainees have become international leaders in the field of cardiovascular disease prevention. In collaboration with Harvard-Chan School of Public Health I have been awarded the  prestigious Geo Health grant to build capacity in air pollution research.  In addition, I lead the globally acclaimed Primary Care Physician Program in several areas of Chronic Diseases . This program has trained more than 25000 primary care physicians in India and is now being scaled up to other countries including Nepal, Myanmar, Rwanda and Kenya. This program has received the highest awards from all the Chambers of Commerce and the Quality Council of India. In the last 10 years I have raised grants worth more than 20 million US dollars for capacity building. In addition, I am an avid teacher. I was  the lead editor of a two volume 1600 page comprehensive text book titled “Tandon’s Text Book of Cardiology” which was published recently. This book is a comprehensive text book for cardiologists in training and practice and emphasizes the unique need of Indian cardiologists.

Contributions to Policy

I am actively engaged in policy advocacy and have contributed to 4/11 modules on non-communicable diseases for health policy makers by WHO and actively participated as a resource person in their program for South Asia. This is an active role that I take in connecting our science with policy and practice, so that the data we gather has more than just academic value. I have been instrumental in preparing the South Asia regional policy note for the World Bank on non-communicable diseases by extensively contributing to the sections on Nepal and India. Under my editorial leadership The World Bank published Cardiovascular Disease volume of the latest Disease Control Priorities Project. This volume estimates cost effectiveness of available interventions and provides a summary to policy makers across the world to   prioritize their investments.

Administrative capabilities

As Director of Centre for Chronic Disease Control and Vice President at the Public Health Foundation of India I perform several administrative roles. I lead a team of over 100 researchers who are in involved in Chronic Disease research, training and capacity building. I am actively involved in developing policy at PHFI, ensure high standards of ethics in research and recognition of IP rights,  and guide the budgeting process. I participate and represent the management at board meetings. 

Role as Executive Director IC Health (Initiative for Cardiovascular Health Research in the Developing Countries):2007-2013

As Director of IC Health, I was involved in fund raising, development of new projects and co-ordination of existing projects.  IC Health through its research facilitation process established networks across 24 developing countries for CVD research.

The major project completed in 2009 was a World Bank funded macro-economics of Cardiovascular Diseases which had three components: a) A macroeconomic modelling for the loss in GDP due to CVD’s in India, China, Argentina, Ukraine and Tanzania (published in PloS One 2011), b) A microeconomic assessment of CVD on individuals and families in 4 countries, and c) A business model for trans-fat reduction, tobacco control and Community health workers in the management of hypertension.   As a member of the steering committee, I was involved in the administrative and financial management of IC Health projects.

The second major project was Global Cardiovascular Disease Research Survey: Phase II” funded by the Global Forum for Health Research (total funding: USD 124,612). Completed in 2012. A bibliometric approach was developed for tracking publications in CVD across the world. This resulted in 3 important publications (JAHA 2015, Arq Bras Cardiol. 2015, Glob Heart. 2014 and PLoS One. 2013). This tool could be adopted to any country setting.

 

Departmental Activities as a Faculty Member at AIIMS

As a faculty member at AIIMS, my routine activities included clinical care, teaching research and administrative work. I was a preceptor or guide for several DM (Cardiology) and MCH (Cardio thoracic Surgery), MD internal medicine and PHD Students. After AIIMS, I had a part time clinical attachment as a Senior Consultant Cardiologist at Sitaram Bhartiya Institute of Science and Research (large private tertiary care centre in Delhi) from 2007-2014. This included Outpatient services and Echocardiography.

Major Research Projects (completed)

 

National Funding:

• Co-investigator in the ICMR Multi-centric study of prevalence of coronary heart disease and coronary risk factors in India. (1994)
• Co-investigator in the Bharat Electronics Limited Coronary Heart Industrial Population Study (BEL-CHIPS). The study involved a cross-sectional survey of prevalence of coronary heart disease and distribution of risk factors as well as a prospective follow-up (1994 – 1999)
• Co-Investigator in project HRIDAY (Health Related Information Dissemination Amongst Youth). This study involves an educational campaign to promote a healthy lifestyle amongst school children in Delhi and a research component to evaluate the efficacy of this programme. (1994)
• Principal Investigator (May 1999 onwards) of Indian Council of Medical Research Multicentre collaborative case control study on coronary risk factors in acute myocardial infarction. (Funding agency: ICMR; 1997- 2002)
• Co-Principal Investigator of the project titled “Establishment of Sentinel Surveillance in Indian Industries”. This project is funded by WHO and the government of India and aimed to establish a surveillance system in 10 industrial sites across India. (2001- 2008) (Total funding USD 3,50,000). The findings of this study were published in JACC in 2009 and the worksite program that was developed in this program has been cited as an example to emulate in the World Economic Forum (2008) and the IOM document “Promoting Cardiovascular Health in the Developing World A Critical Challenge to Achieve Global Health” in 2010
• Co-Principal investigator in the South Delhi initiative project “Chronic disease detection and prevention programme for Malviya Nagar Residents, New Delhi”. An initiative of All India Institute of Medical Sciences and RWA- Malviya Nagar (Funding agency WHO: USD 20,000; 2004)
• Co-Principal Investigator of Detection and Management of Coronary Heart Disease patients (DEMAT) sponsored by MSD Pharmaceuticals Ltd; (2007-2008)
• Co-Principal Investigator of Unilever funded study “Effect of Omega-3 fatty acids supplements and plant sterol enriched food in dyslipidemic adults” (December 2006-March 2008)
• Principal Investigator:  Cluster RCT to evaluate the efficacy of dietary intervention through Information Education Communication (IEC) tools with Angan Wadi Centres (AWCs) as the centre of knowledge dissemination for hypertension risk reduction (Funding Agency: ICMR, Rs 6993474; approx. 140000 USD). Start/End date: January 2012-December 2017. 

International Funding

• Co-Investigator of the British Heart Foundation Project: Maternal Nutrition, Foetal Growth and coronary risk factors in Young Indian Adults. (Funding agency: British Heart Foundation; From 1998 – September 2002)
• Co-Investigator of British Heart Foundation funded study Coronary Risk Factor Comparison in migrant and rural South Asians: the Indian limb of the Gujarat Heart study (in collaboration with University of Manchester, UK) (Funding agency: British Heart Foundation; From 1998 –March 2002)
• Principal Investigator (Delhi centre) of an International Registry of Acute Ischemic Coronary syndrome (OASIS Registry) (Funding agency: Canadian Cardiovascular Collaboration; 1999- Dec 2002)
• Co- Investigator of NIH funded India Health Study which aims to assess the feasibility of establishing a cohort in Delhi, Trivandrum and Mumbai to study the dietary determinants of cancer.  (Funding agency: National Cancer Institute; NIH; 2006-2009)
• National Leader of the International trial “Early ACS’ trial coordinated by the Duke Cardiovascular research institute, Durham, USA (2007-2009)
• National Leader of the International trial “Rocket AF” trial coordinated by the Duke Cardiovascular research institute, Durham, USA.
• Co-investigator of the Indian-migrant study.  This study has collected phenotypic data on 6500 individuals, and by its sib-pair, index-spouse design is uniquely positioned to study the genetic and environmental influences CVD risk factor (Funding agency: Wellcome Trust) 2004-2008
• Co-Investigator in “Nutritional challenges, abdominal adiposity and type 2 diabetes in Indians” a collaboration between London School of Hygiene and tropical Medicine, National institute of Nutrition (Hyderabad), St Johns Medical College Bangalore, the University of Bristol, All India Institute of Medical sciences Delhi, CCDC Delhi, the Institute of Child Health, and the MRC Clinical Sciences Centre. (2008-2011) (Funding agency: Wellcome Trust)
• Regional leader and executive committee member of the STICH trial which compared bypass surgery and best medical therapy in patients with Heart failure (Funding agency: National Heart Lung and Blood Institute; NIH:  India funding 880000 USD; 2004-2011)
• Co-Investigator “Environmental and genetic determinants of obesity and diabetes in India” (Funding agency: Wellcome Trust: 2008-2011)

• Principal Investigator of the NHLBI and United Health Group Strategic grant for Establishment of Centre for prevention of Cardio-metabolic diseases in South Asians (A collaborative project of Emory University, Public Health Foundation of India, AIIMS, Mohan’s diabetic centre and Aga Khan University, Karachi) Funding: 4.2 million USD over 5 years. Start; June 2009. Completed September 2014 
• Principal Investigator: PHFI-Emory Partnership for Seamless, Thorough and Efficient Human Subjects Research; Funding: Fogarty International Centre (NIH): USD 54170. Start; September 2010. Completed September 2012
• Co- Investigator, Simplified Cardiovascular Management Study (SIMCARD): This study evaluated low cost treatment strategies in the management of Hypertension at Haryana in India and Tibet in China. Funding NHLBI: 500000 USD:  June 2012- June 2014 
• Co-National Leader and Co-applicant for UMPIRE trial (“Use of a Multidrug Pill In Reducing cardiovascular Events”) – A phase 3 – randomised controlled clinical trial of fixed-dose combination medication and usual care in patients at high risk of cardiovascular disease. Centrally coordinated by Imperial College London and funded by European Commission, Brussels. Total Funding: 3 million Euro; India:880000 Euro (March 2010- March 2013) 
• Principal Investigator: A health system intervention project to reduce CVD in Solan District of Himachal Pradesh funded by the Medtronic Foundation. Funding 300000 USD for 2 years.  (2011-2013)
• Principal Investigator: Genetic markers of lipids in Indians: a validation study of most relevant findings of genome-wide association studies Funding: CSIR: Rs.3.3 million (660000 USD); 2011-2013
• Co-Investigator: Prevention of type 2 diabetes in women with gestational diabetes using Health promotion techniques in urban India – a feasibility study: Funding IDF: 65000 USD; 2013-2015 
• National Leader and Steering Committee member: INTERCHF (in collaboration with McMaster university): This was a large international registry of Heart Failure. 2014-2016
• National Leader: STICHES trial (Surgical treatment for ischemic heart failure) Funding NHLBI: 233550 USD for India. 2012-2016  
• National Leader and Co applicant of the International trial CORONARY (“CABG off or on pump revascularization study”) which aims to compare the 2 techniques – Off-pump CABG with on-pump CABG, and determine which technique reduces major clinical vascular events in the short term (30 days) and over a longer term (5 years).  Coordinated by Population Health Research Institute, McMaster University, Canada. Funding for CCDC: 50000 USD; 2007-2014 
• Principal Investigator: Genetic Association Study of Polymorphisms related to Chronic Obstructive Pulmonary Disease COPD in North Indian Population (COPD Genetic Consortium study): Funding agency: DBT: Rs. 8.5 million approx.: 170000 USD. 2012-2016 
• Co-Investigator: Acute Coronary Syndrome Quality Improvement in Kerala: Aims to improve the quality of care for ACS at secondary and tertiary care hospitals (Funding: NHLBI; 800000 USD). 2011-2016 
• Chief-Investigator-C: Effectiveness, cost-effectiveness and acceptability of a simplified strategy using a low-dose combination 3-in-1 antihypertensive pill (“Triple Pill”) for the management of hypertension in urban India (with George Institute, India); (Funding agency NHMRC, Australia; AU$ 1,067,559 ). 2012-2017 
• Chief-Investigator-C: Effectiveness of an innovative and multidisciplinary program addressing BP control in rural India (with George Institute, India; Funding agency NHMRC, Australia. AU$ 930,259). 2012-2015
• Chief-Investigator-D: Developing a salt reduction program for India (with George Institute, India, and PHFI; Funding agency NHMRC, Australia). 2012-2014
• Network Co-investigator and Steering Committee Member: SHARE Study (South Asian Hub for Advocacy, Research and Education on Mental Health) Funding by National Institute of Mental Health. 2012-2017  
• Principal Investigator: Association of persistent organic pollutants with incident diabetes among urban Indian adults. This is a joint Project of Indian Council of Medical Research (ICMR) and NIDDK, NIH Funding: 120000 USD. Start/End date: 2016-02-22 – 2019-01-31
• Principal Investigator: mWELLCARE – An integrated mHealth system for the prevention and care of chronic conditions: Funding: Wellcome Trust; Rs. 102 million (1.2 million GBP).  In partnership with London School of Hygiene and Tropical Medicine.  Start/End date: September 2014- September 2018
• Principal Investigator: Yoga-CaRe Trial; A clinical trial of yoga-based cardiac rehabilitation program on cardiovascular health in India and mechanistic study in UK. Funding: ICMR, MRC-UK Combined funding approx. 1 million GBP in partnership with London School of Hygiene and Tropical Medicine.  Start/End date: September 2014- August 2018 
• Collaborator: Txt2Heart pilot study: An international study to develop and pilot tailored text message to improve adherence to medications in cardiovascular secondary prevention. In collaboration with LSHTM. Start/End date: April 2016- March 2018

Ongoing Major Research Projects 

• Co-applicant/Co-Investigator: Sustainable and Healthy Food Systems (SHEFS): It is one of four major interdisciplinary research partnerships in the areas of global food systems and urbanization awarded by the Wellcome Trust in 2017. Funding: 4.5 million GBP. Start/End date: May 2017 – April 2022 
• Co- Principal Investigator of an NCI funded planning grant titled “Planning a Regional Centre of Research Excellence in Non-Communicable Diseases in India” Funding: 289628 USD. Start/End date: 2016-09-21- 2019-08-31
• Principal Investigator (India): Childhood and young adult predictors of myocardial structure and function at age 45 years in the New Delhi and Vellore Birth Cohorts, India. Funding: British Heart Foundation; India Funding: approx. 500000 Start/End date: 2016/06/01 – 2019/05/31
• Principal Investigator (multi PI program): Air pollution and health: GeoHealth hub research and capacity building (1U2RTW010108-01) Funding: National Institute of Health; 3000000 USD. Start/End date: 2015/09/28 – 2020/07/31 
• Co-Principal Investigator: Worksite lifestyle program for reducing diabetes and cardiovascular risk in India (1R01HL125442-01A1; National Heart, Lung, and Blood Institute) Funding: NHLBI; 1500000 USD. Start/End date: 2015-09-01- 2020-05-31.
• Co-Principal investigator: UDAY (Comprehensive Diabetes Prevention and Management Program): A multi-component, multi-level, comprehensive intervention program to improve the prevention, detection and optimal management of diabetes. Funding:  Eli Lilly and Company Foundation: USD 7.5 million. Start/End date: June 2012- December 2018
• Principal Investigator : A cluster randomized trial of an mHealth integrated model of hypertension, diabetes and antenatal care in primary care settings in India and Nepal; Funding: DBT-DFID-ESRC-MRC through their   Global Research Programme INR 50,000,000 Start/End date: April 2019- March 2022
• Co-Investigator : Integrated Tracking, Referral, and Algorithmic Management (I-TREC) System for Hypertension and Diabetes. Funding: NHLBI Start/End date : September 2017-May 2022 

Capacity Building grants:

Past:

• Co-Investigator: Research capacity building and establishment of networks in 24 developing countries (Global Forum for Health Research & World Bank); 2007-2014
• International Director: Fogarty International Clinical Research Training Site (2009-2012): Mentored 18 international and national scholars and fellows. They have done exceedingly well, and the achievements include high impact publications; obtaining prestigious K awards, R00 grants, fully funded scholarship for a PHD at Oxford University among others.
• Coordinator: Annual teaching seminar on CVD Epidemiology and Research Methods (2009-2013) at Centre for Chronic Disease Control
• Mentor: Effect of Docosa-hexaenoic acid (DHA) Supplementation during pregnancy on New born outcomes in India – the DHANI RCT). Funding agency: DBT
• Co-Investigator and EC member (2009-2014): Millennium Promise Award from the NIH, through the prestigious D-43 Grant Mechanism of Fogarty International Centre. The partners in this program were Centre for Chronic Disease Control (CCDC); Public Health Foundation of India (PHFI); EMORY University, Atlanta, USA; All India Institute of Medical Sciences, New Delhi (AIIMS) and Madras Diabetic Research Foundation (MDRF). This program provided interdisciplinary training program with focus on the epidemiology and prevention of NCDs across the life-course in cross-connecting subject areas and provide short term training to 8 junior faculty researchers & long-term training to 10 post-doctoral fellows. The total grant was 1.1 Million USD over 5 years. 7 junior faculty and 4 post-doctoral fellows completed their training under this scheme and 6 post-doctoral fellows are currently in training. These trainees have been highly successful by publishing nearly 100 papers over 4 years and generating nearly 1.5 million dollars of grant.
• Program Director (2011-2016):  Public Health Leadership and Development Academy for NCDs, Public Health Foundation of India. The PH Leader Program is a joint program of Emory University, PHFI and National Institute of Public Health, Mexico funded by Fogarty International Centre.
• Program Director: Wellcome Trust Research Capacity Building Project at PHFI in Collaboration with London School of Hygiene and Tropical Medicine . End date: November 2018

Current:

• Senior Program Director (Primary care Physician Training Programs):  I am Senior program Director of several primary physician programs. These include Certificate courses in diabetes, gestational diabetes, diabetic retinopathy, hypertension, thyroid disorders, chronic obstructive lung diseases and others.  Through these we have reached out to more than 22000 primary and secondary care physicians all across India. I am the India lead for the course on Health Emergencies in Large Populations (HELP) conducted in collaboration with the International Committee of the Red Cross. These courses have received several accolades and awards, and have been adopted by several state governments of India. Some of these courses will be rolled out in several African countries (the Hypertension course through the Pan African Society of Cardiology in Africa and Pakistan by Pakistan Society of hypertension; the diabetes training programs in Nepal, Myanmar and East Africa. These programs have variable start times and the last program to end will be in March 2022
• Director and Co-Program Investigator – Certificate Course in Evidence Based Management of Diabetic Retinopathy- CCDR funded The Queen Elizabeth Diamond Jubilee Trust (QEDJT); in collaboration with London School of Hygiene and Tropical Medicine. End date: December 2018 
• Faculty: Ten Day International Teaching Seminar on   Cardiovascular Disease Epidemiology and Prevention organized by the International Society of Cardiovascular Epidemiology and Prevention
• Network Investigator: R25 (capacity building project in collaboration with a consortium of US Universities: Emory, Vanderbilt, Cornel and Duke Universities)

Programs: 

• Principal Investigator: WHO Collaborating Centre for Surveillance, Capacity Building and Translational Research in Cardio-metabolic Diseases (WHOCC No. IND-124) from 2014 onwards.
• Principal Investigator:  Centre of Excellence in Clinical Research Funded by Department of Bio Technology India from 2015 -2018. Further funding under consideration

 

Mentorship: 

In a span of 20 years I have mentored approximately 50 pre-doctoral, post- doctoral and junior faculty in cardiovascular disease research and epidemiology. Several of them have become leaders in their own right. Their research spans areas that are relevant to India including tobacco control, gathering evidence for salt reduction, dietary interventions and health system interventions.

Memberships 

• Member Scientific Advisory Board of the Indian Council of Medical Research
• Chair of CVD group in India for estimating State Level Disease Burden
• Member of the Diabetes group in India for estimating State Level Disease Burden
• Member of the Air Pollution in India for estimating State Level Disease Burden
• Special Invitee in advisory capacity to the steering committee overseeing the National Programme for Prevention of Cardiovascular diseases and Diabetes in 2007 and 2008 (this program is a major program of the Ministry of Health, Government of India)
• Member Capacity Building Sub Committee of the National Programme for Prevention of Cardiovascular diseases and Diabetes 2007
• Global Burden of Disease Study on the analysis of the burden of Ischemic Heart Disease as part the Global Burden of Diseases, Injuries, and Risk Factors for 2005 as Co-author
• Member, Scientific Advisory Committee of Initiative for Cardiovascular Health Research in the Developing Countries (2006-2013)
• Member of Surgical Treatment for Ischemic Heart Failure International Steering Committee
• Member of the Trilogy ACS Executive Committee
• Member of Oxford Health Alliance
• Member, Cardiological Society of India
• Founder member of Health-Related Information Dissemination Among Youth (HRIDAY) a Non-Government organization of health professionals and social scientists engaged in activities aiming to promote health awareness and informed health activism among school and college students in India which in turn assist the World Health Organization (WHO) and the Ministry of Health and Family welfare (Government of India) in various health promotion programmes.
• Member, Association of Physicians of India
• Member, of scientific Council of the section on Epidemiology and prevention of the World Heart Federation from 1997 onwards.
• Member of Indian Council of Medical Research’s Project Review Committee on Cardiology
• Member of Indian Council of Medical Research’s Advisory Committee on Hypertension.
• Founder member and Joint Secretary of Centre for Chronic Disease Control.

Editorial/Review Work for Medical Journals 

• Member, Editorial Board: Nature Cardiology Reviews ( June 2018 onwards)
• Member Editorial Board: JAMA Cardiology ( 2017 onwards)
• Associate Editor, International Journal of Epidemiology Jan 2017-June 2018
• Editor, Cardiovascular and Respiratory Diseases Volume, Disease Control Priorities in Developing Countries (DCP3).
• Co-Editor: Global Heart which is a World Heart Federation Journal (2011, 2012)
• Editor: World bank-PHFI policy note series on NCDs.
• Guest Editor for Indian Journal of Medical Research (IJMR) for the Special Issue on Cardiovascular Diseases (December 2010).
• Guest Editor for Current Science for the Special Issue on Cardiovascular Diseases, published on August 2009.
• Associate Editor, Journal of Epidemiology and Community Health (JECH); a BMJ journal (2008-2011)
• Member Editorial Board (2002-2005) Indian Heart Journal and 2009 onwards.
• Member Editorial Board: Open Medicine till 2009.
• Member Editorial Board: Clinical Science from 2009.
• Referee for Scientific paper assessment: Lancet, International Journal of Cardiology, Circulation, Atherosclerosis, American Heart Journal, Plos Medicine, National Medical Journal of India, Indian Heart Journal, Journal of Hypertension, Journal of the National Academy of Medical Sciences, Indian journal of Medical Research.

Assistance to National and International Agencies

• World Health Organisation (WHO)
• Government of India
• Government of Karnataka
• Government of Kerala
• World Bank
• Wellcome Trust

SAARC Cardiological Society Guidelines Committee 

Co-regional co-ordinator for the SAARC (South Asian Association for Regional Cooperation): Guidelines Committee on prevention of cardiovascular diseases in South Asians. The Guidelines were presented in the SAARC biennial conference held at New Delhi from 10th – 13th February 2002

Extra-Mural Academic Contributions

• Editorial Advisor to the Indian Heart Journal on Cardiovascular Epidemiology
• Technical expert for review of ICMR (Indian Council of Medical Research) projects in Cardiology.

Other Contributions

• Member of the Core Group that developed a web based dietary guide both for health individuals as well as for patients http://www.foodpyramidindia.org/credits.html
• Co-established the network of Indian Industries for surveillance of cardiovascular disease.
• Significantly contributed to the report on National Consultation on diet and physical activity
• Developed guidelines for medical officers on prevention and management of cardiovascular diseases and diabetes to be implemented at primary and community health centres in India. This was done through a consensus workshop under the National programme for Prevention of Cardiovascular diseases, Diabetes and Stroke.

Orations/lectures/faculty role

• Keynote speaker at the Fogarty @ 50 event in AHA 2017, Anaheim, CA to celebrate the 50^th year of Fogarty International. Title of the topic “Global Cardiovascular research and training to achieve global heart health goals” on 14/11/2017
• Public Colloquium at Stanford University titled “Strategies and tactics to address the chronic disease burden in India” on 8/11/2017
• Several talks in the American Heart Association, American College of Cardiology, European Society of Cradiology, World Congress of Cardiology and Cardiology Society of India meetings in the last 20 years
• Grand rounds in the departments of public health, Epidemiology, preventive Medicine or Cardiology (from 2010 onwards):

• • University of Manchester ( Manchester, UK)
  • CAITE lecture, University of Bristol (Bristol, UK),
  • St. Mary’s Hospital, Imperial College (London, UK),
  • University of Glasgow (Glasgow, UK),
  • Rollins School of Public Health, Emory University (Atlanta, USA),
  • North Western University (Chicago, USA),
  • University of Michigan (Ann Arbor, USA),
  • University of California (Irvine, USA),
  • University of Canberra (Canberra, Australia),
  • University of Melbourne (Melbourne, Australia),
  • Ohio State University (Ohio, USA).
  • University of British Columbia ( Vancouver, Canada)
  • University of Washington (Seattle, USA)
  • Stanford University ( San Francisco, USA)
  • Population Health Research Institute ( PHRI), McMaster University ( Hamilton, Canada)
  • Simon Fraser University ( Vancouver, Canada)
  • McMaster University, Canada
  • University of Texas-South Western ( Dallas, USA)
  • University of Andes ( Bogota, Columbia)
• World Bank, Washington (video streamed across other offices): A talk on NCD in developing countries in 2014
• Faculty in the annual Ten Day International Teaching Seminar on Cardiovascular Epidemiology:
  • 2009 (Hyderabad, India);
  • 2012 (Cape Town);
  • 2013 (Seoul, South Korea);
  • 2014 (Coorg, India);
  • 2015 (Nadi, Fiji),
  • 2017 (Kuala Lumpur, Malaysia)
  • 2018 (Goa)

 

Publications: >500 publications , 2 books and 2 monographs with an H-index of 83 and >95000 citations

Fifty Key Publications in high impact journals or with high citations and with societal impact.

1. Unger T, Borghi C, Charchar F, Khan NA, Poulter NR, Prabhakaran D, Ramirez A, et al. 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension. 2020 May 6:HYPERTENSIONAHA12015026. doi: 10.1161/HYPERTENSIONAHA.120.15026. [Epub ahead of print] PubMed PMID: 32370572.
2. Prabhakaran D, Chandrasekaran AM, Singh K, Mohan B, Chattopadhyay K, Chadha DS, Negi PC et al. ; Yoga-CaRe Trial Investigators. Yoga-Based Cardiac Rehabilitation After Acute Myocardial Infarction: A Randomized Trial. J Am Coll Cardiol. 2020 Apr 7;75(13):1551-1561. doi: 10.1016/j.jacc.2020.01.050. PubMed PMID: 32241371; PubMed Central PMCID: PMC7132532.
3. Jaacks LM, Yadav S, Panuwet P, Kumar S, Rajacharya GH, Johnson C, Rawal I, Mohan D, Mohan V, Tandon N, Barr DB, Narayan KMV, Prabhakaran D. Metabolite of the pesticide DDT and incident type 2 diabetes in urban India. Environ Int. 2019 Dec;133(Pt A):105089. doi: 10.1016/j.envint.2019.105089. Epub 2019 Oct 22. PubMed PMID: 31654984; PubMed Central PMCID: PMC6860016.
4. Jindal D, Roy A, Ajay VS, Yadav SK, Prabhakaran D*, Tandon N*. Strategies for Stakeholder Engagement and Uptake of New Intervention: Experience From State-Wide Implementation of mHealth Technology for NCD Care in Tripura, India. Glob Heart. 2019 Jun;14(2):165-172. doi: 10.1016/j.gheart.2019.06.002. PubMed PMID: 31324371 * Joint senior authors
5. Mohanan PP, Huffman MD, Baldridge AS, Devarajan R, Kondal D, Zhao L, Ali M, Joseph J, Eapen K, Krishnan MN, Menon J, Thomas M, Lloyd-Jones DM, Harikrishnan S, Prabhakaran D; ACS QUIK Investigators. Microeconomic Costs, Insurance, and Catastrophic Health Spending Among Patients With Acute Myocardial Infarction in India: Substudy of a Randomized Clinical Trial. JAMA Netw Open. 2019 May 3;2(5):e193831. doi: 10.1001/jamanetworkopen.2019.3831. PubMed PMID: 31099866.
6. Agarwal A, Huffman MD, Reddy KS, Prabhakaran D. The 2017 American College of Cardiology/ American Heart Association Clinical Practice Guideline for Blood Pressure: Implications for India. Natl Med J India. 2018 May-Jun;31(3):129-132. doi: 10.4103/0970-258X.255751. PubMed PMID: 31044756.
7. Beaney T, Burrell LM, Castillo RR, Charchar FJ, Cro S, Damasceno A, Kruger R, Nilsson PM, Prabhakaran D, Ramirez AJ, Schlaich MP, Schutte AE, Tomaszewski M, Touyz R, Wang JG, Weber MA, Poulter NR; MMM Investigators . May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure  by the International Society of Hypertension. Eur Heart J. 2019 May 1. pii: ehz300. doi: 10.1093/eurheartj/ehz300. [Epub ahead of print] PubMed PMID: 31041440.
8. Jose AP, Awasthi A, Kondal D, Kapoor M, Roy A, Prabhakaran D, Impact of repeated blood pressure measurement on blood pressure categorization in a population-based study from India. J Hum Hypertens. 2019 Apr 12. doi:10.1038/s41371-019-0200-4. [Epub ahead of print] PubMed PMID: 30979950.
9. Prabhakaran D, Ajay VS, Tandon N. Strategic Opportunities for Leveraging Low-cost, High-impact Technological Innovations to Promote Cardiovascular Health in India. Ethn Dis. 2019 Feb 21;29(Suppl 1):145-152. doi: 10.18865/ed.29.S1.145. eCollection 2019. PubMed PMID: 30906163; PubMed Central PMCID: PMC6428188
10. Beaney T, Schutte AE……………Prabhakaran D, Ramirez AJ, Schlaich MP, Wang J, Weber MA, Poulter NR; MMM Investigators. May Measurement Month 2017: an analysis of blood pressure screening results worldwide. Lancet Glob Health. 2018 May 16. pii: S2214-109X(18)30259-6. doi: 10.1016/S2214-109X(18)30259-6. [Epub ahead of print] PubMed PMID: 29778399.
11. Jamison DT, Alwan A, ………………Prabhakaran D, Qi J, Reynolds T, Ruacan S, Sankaranarayanan R, Sepúlveda J, Skolnik R, Smith KR, Temmerman M, Tollman S, Verguet S, Walker DG, Walker N, Wu Y, Zhao K. Universal health coverage and intersectoral action for health: key messages from Disease Control Priorities, 3rd edition. Lancet. 2017 Nov 24. pii: S0140-6736(17)32906-9. doi:10.1016/S0140-6736(17)32906-9. [Epub ahead of print] Review. PubMed PMID:29179954.
12. India State-level Disease Burden Initiative Collaborators. Nations within a nation: variations in epidemiological transition across the states of India, 1990-2016 in the Global Burden of Disease Study. Lancet. 2017 Nov 13. pii: S0140-6736(17)32804-0. doi: 10.1016/S0140-6736(17)32804-0. [Epub ahead of print] PubMed PMID: 29150201. (Prabahakaran D, Chair Cardiovascular Disease group)
13. Prabhakaran D, S Anand, TA Gaziano. J-C Mbanya, Y Wu, and R Nugent. 2017. Cardiovascular, Respiratory, and Related Disorders. Disease Control Priorities, (third edition), Volume 5. Washington, DC: World Bank. doi:10.1596/978-1-4648-0518-9. License: Creative Commons Attribution CC BY 3.0 IGO.
14. India State-Level Disease Burden Initiative CVD Collaborators. The changing patterns of cardiovascular diseases and their risk factors in the states of India: the Global Burden of Disease Study 1990-2016. Lancet Glob Health. 2018 Sep 11. pii: S2214-109X(18)30407-8. doi: 10.1016/S2214-109X(18)30407-8. [Epub ahead of print] PubMed PMID: 30219317.
15. Prabhakaran D, Jha D, Prieto-Merino D, Roy A, Singh K, Ajay VS, Jindal D, et al. Effectiveness of an mHealth-Based Electronic Decision Support System for Integrated Management of Chronic Conditions in Primary Care: The mWellcare Cluster-Randomized Controlled Trial. Circulation. 2018 Nov 10. doi: 10.1161/CIRCULATIONAHA.118.038192. [Epub ahead of print] PubMed PMID: 30586732.

1. Huffman MD, Mohanan PP, …………………… Lloyd-Jones DM, Prabhakaran D; Acute Coronary Syndrome Quality Improvement in Kerala (ACS QUIK) Investigators. Effect of a Quality Improvement Intervention on Clinical Outcomes in Patients in India With Acute Myocardial Infarction: The ACS QUIK Randomized Clinical Trial. JAMA. 2018 Feb 13;319(6):567-578. doi:10.1001/jama.2017.21906. PubMed PMID: 29450524.

17. Patel SA, Dhillon PK, …………… Patel V, Prabhakaran D. Chronic disease concordance within Indian households: A cross-sectional study. PLoS Med. 2017 Sep 29;14(9):e1002395. doi: 10.1371/journal.pmed.1002395. eCollection 2017 Sep. PubMed PMID: 28961237.
18. Prabhakaran D, Jeemon P, Ghosh S, Shivashankar R, Ajay VS, Kondal D, Gupta R et al. Prevalence and incidence of hypertension: Results from a representative cohort of over 16,000 adults in three cities of South Asia. Indian Heart J. 2017 Jul – Aug;69(4):434-441. doi: 10.1016/j.ihj.2017.05.021. Epub 2017 May 30. PubMed PMID: 28822507; PubMed Central PMCID: PMC5560901.
19. Prabhakaran D, Roy A, Praveen PA, Ramakrishnan L, Gupta R, Amarchand R, Kondal D, et al. 20-Year Trend of Cardiovascular Disease Risk Factors: Urban and Rural National Capital Region of Delhi, India. Glob Heart. 2017 Apr 11. pii: S2211-8160(16)30787-6. doi: 10.1016/j.gheart.2016.11.004. [Epub ahead of print] PubMed PMID: 28411147.
20. Mendenhall E, Kohrt BA, Norris SA, Ndetei D, Prabhakaran D. Non-communicable disease syndemics: poverty, depression, and diabetes among low-income populations. Lancet. 2017 Mar 4;389(10072):951-963. doi: 10.1016/S0140-6736(17)30402-6. Review. PubMed PMID: 28271846.
21. Liu NH, Daumit GL, ………………..Prabhakaran D, Pratt K, Prince M, Rangaswamy T, Shiers D, Susser E, Thornicroft G, Wahlbeck K, Fekadu Wassie A, Whiteford H, Saxena S. Excess mortality in persons with severe mental disorders: a multilevel intervention framework and priorities for clinical practice, policy and research agendas. World Psychiatry. 2017 Feb;16(1):30-40. doi: 10.1002/wps.20384. PubMed PMID: 28127922; PubMed Central PMCID: PMC5269481.
22. Ajay VS, Jindal D, Roy A, Venugopal V, Sharma R, Pawar A, Kinra S, Tandon N, Prabhakaran D. Development of a Smartphone-Enabled Hypertension and Diabetes Mellitus Management Package to Facilitate Evidence-Based Care Delivery in Primary Healthcare Facilities in India: The mPower Heart Project. J Am Heart Assoc. 2016 Dec 21;5(12). pii: e004343. doi: 10.1161/JAHA.116.004343. PubMed PMID: 28003248.
23. Lamy A, Devereaux PJ, Prabhakaran D, Taggart DP, Hu S, Straka Z, Piegas LS, et al; CORONARY Investigators. Five-Year Outcomes after Off-Pump or On-Pump Coronary-Artery Bypass Grafting. N Engl J Med. 2016 Dec 15;375(24):2359-2368. PubMed PMID: 27771985.
24. Ali MK, Singh K, Kondal D, ………………….., Prabhakaran D, Narayan KM, Tandon N; CARRS Trial Group. Effectiveness of a Multicomponent Quality Improvement Strategy to Improve Achievement of Diabetes Care Goals: A Randomized, Controlled Trial. Ann Intern Med. 2016 Jul 12. doi: 10.7326/M15-2807. [Epub ahead of print] PubMed PMID: 2739887
25. Prabhakaran D, Jeemon P, Roy A. Cardiovascular Diseases in India: Current Epidemiology and Future Directions. Circulation. 2016 Apr 19;133(16):1605-20. doi: 10.1161/CIRCULATIONAHA.114.008729. PubMed PMID: 27142605.
26. Bhalla S, Unnikrishnan R, Srivastava R, Tandon N, Mohan V, Prabhakaran D. Innovation in capacity building of primary-care physicians in diabetes management in India: a new slant in medical education. Lancet Diabetes Endocrinol. 2016 Jan 19. pii: S2213-8587(15)00514-8. doi: 10.1016/S2213-8587(15)00514-8. [Epub ahead of print] PubMed PMID: 26868978.
27. Poulter NR, Prabhakaran D, Caulfield M. Hypertension. Lancet. 2015 Mar 27. pii: S0140-6736(14)61468-9. doi: 10.1016/S0140-6736(14)61468-9. [Epub ahead of print] Review. PubMed PMID: 25832858.
28. Anand S, Shivashankar R, ………………………. Prabhakaran D. Prevalence of chronic kidney disease in two major Indian cities and projections for associated cardiovascular disease. Kidney Int. 2015 Mar 18. doi: 10.1038/ki.2015.58. [Epub ahead of print] PubMed PMID: 25786102.
29. Chowdhury R, ……………………….. Prabhakaran D, Hoshen MB, Feldman BS, Pan A, Johnson L, Crowe F, Hu FB, Franco OH. Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ. 2014 Apr 1; 348: g1903. doi: 10.1136/bmj.g1903. PubMed PMID: 24690623.
30. Anchala R, Kannuri NK, Pant H, Khan H, Franco OH, Di Angelantonio E, Prabhakaran D. Hypertension in India: a systematic review and meta-analysis of prevalence, awareness, and control of hypertension. J Hypertens. 2014 Mar 11. [Epub ahead of print] PubMed PMID: 24621804.

1. Lamy A, Devereaux PJ, Prabhakaran D, Taggart PD, Hu S, Paolasso, et al.for the CORONARY Investigators. Effects of Off-Pump and On-Pump Coronary-Artery Bypass Grafting at 1 Year N Engl J Med 2013. DOI: 10.1056/NEJMoa1301228

32. Mohanan PP, Mathew R, ………………………. Huffman MD, Prabhakaran D; Kerala ACS Registry Investigators. Presentation, management, and outcomes of 25 748 acute coronary syndrome admissions in Kerala, India: results from the Kerala ACS Registry. Eur Heart J. 2013 Jan;34(2):121-9. doi: 10.1093/eurheartj/ehs219. Epub 2012 Sep 7. PubMed PMID: 22961945; PubMed Central PMCID: PMC3538274.

1. Thom S, Field J, Poulter N, Patel A, Prabhakaran D, Stanton A, Grobbee DE, et al. Use of a Multidrug Pill In Reducing cardiovascular Events (UMPIRE): rationale and design of a randomised controlled trial of a cardiovascular preventive polypill-based strategy in India and Europe. Eur J Prev Cardiol. 2012 Oct 4. [Epub ahead of print] PubMed PMID: 23038750.
2. Nair M, Ali MK, ……………..Narayan KM, Prabhakaran D. CARRS Surveillance study: design and methods to assess burdens from multiple perspectives. BMC Public Health. 2012 Aug 28; 12:701. doi: 10.1186/1471-2458-12-701. PubMed PMID: 22928740; PubMed Central PMCID: PMC3491014.
3. Roe MT, Armstrong PW, Fox KA, White HD, Prabhakaran D, Goodman SG, Cornel JH, et al. TRILOGY ACS Investigators. Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. N Engl J Med. 2012 Oct 4; 367(14):1297-309. doi: 10.1056/NEJMoa1205512. Epub 2012 Aug 25. PubMed PMID: 22920930.
4. Lamy A, Devereaux PJ, Prabhakaran D, Taggart DP, Hu S, Paolasso E, Straka Z, et al.; the CORONARY Investigators. Off-Pump or On-Pump Coronary-Artery Bypass Grafting at 30 Days.N Engl J Med. 2012 Mar 26. [Epub ahead of print] PMID: 22449296
5. Huffman MD, Prabhakaran D, Osmond C, Fall CH, Tandon N, Lakshmy R, Ramji S, et al; New Delhi Birth Cohort. Incidence of Cardiovascular Risk Factors in an Indian Urban Cohort Results from the New Delhi Birth Cohort. J Am Coll Cardiol. 2011 Apr 26;57(17):1765-1774.PMID: 21511113

38. Huffman MD, …………………… Leeder S, Prabhakaran D. A Cross-Sectional Study of the Microeconomic Impact of Cardiovascular Disease Hospitalization in Four Low- and Middle-Income Countries. PLoS ONE 6(6): e20821. 2011; doi:10.1371/journal.pone.0020821

1. Prabhakaran D, Jeemon P, Goenka S, Lakshmy R, Thankappan KR, Ahmed F, Joshi PP, et al. Impact of a worksite intervention program on cardiovascular risk factors: a demonstration project in an Indian industrial population. J Am Coll Cardiol. 2009 May 5; 53(18):1718-28.
2. Velazquez EJ, ……………….. Prabhakaran D, Szwed H, Ferrazzi P, Petrie MC, O’Connor CM, Panchavinnin P, She L, Bonow RO, Rankin GR, Jones RH, Rouleau JL; the STICH Investigators. Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction. N Engl J Med. 2011 Apr 4. PMID: 21463150
3. Patel V, Chatterji S, Chisholm D, Ebrahim S, Gopalakrishna G, Mathers C, Mohan V, Prabhakaran D, Ravindran RD, Reddy KS. Chronic diseases and injuries in India.  Lancet. 2011 Jan 29; 377(9763):413-28. PMID: 21227486
4. McGorrian C, Yusuf S, Islam S, Jung H, Rangarajan S, Avezum A, Prabhakaran D, Almahmeed W, Rumboldt Z, Budaj A, Dans AL, Gerstein HC, Teo K, Anand SS; on behalf of the INTERHEART Investigators. Estimating modifiable coronary heart disease risk in multiple regions of the world: the INTERHEART Modifiable Risk Score. Eur Heart J. 2010 Dec 22. [Epub ahead of print]
5. Ebrahim S, Kinra S, ………………………….., Prabhakaran D, Reddy KS; Indian Migration Study group. The effect of rural-to-urban migration on obesity and diabetes in India: a cross-sectional study. PLoS Med. 2010 Apr 27;7(4) :e1000268.PMID: 20436961
6. Xavier D, Pais P, Devereaux PJ, Xie C, Prabhakaran D, Reddy KS, Gupta R, et al; CREATE registry investigators. Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data. Lancet. 2008; 371:1435-42
7. Joshi P, Islam S, Pais P, Reddy S, Dorairaj P, Kazmi K, Pandey MR, Haque S, Mendis S, Rangarajan S, Yusuf S.  Risk factors for early myocardial infarction in South Asians compared with individuals in other countries. JAMA. 2007 Jan 17;297(3):286-94
8. Reddy K, Prabhakaran D, Chaturvedi V, Jeemon P, Thankappan K, Ramakrishnan L, Mohan B, Pandav C, Ahmed F, Joshi P, Meera R, Amin R, Ahuja R, Das M, Jaison T.  Methods for establishing a surveillance system for cardiovascular diseases in Indian industrial populations. Bull World Health Organ. 2006 Jun; 84(6):461-469.
9. Yusuf S, Hawken S, Ounpuu S, et. al. INTERHEART Study Investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004 Sep 11; 364(9438):937-52.  (Prabhakaran D: Investigator)  
10. Prabhakaran D, Shah P, Chaturvedi V, Ramakrishnan L, Manhapra A, Reddy KS. Cardiovascular risk factor prevalence among men in a large industry of northern India. Natl Med J India. 2005 Mar-Apr; 18(2):59-65.  
11. Prabhakaran D, Yusuf S, Mehta S, Pogue J, Avezum A, Budaj A, Cerumzynski L, et al.  Two-year outcomes in patients admitted with non-ST elevation acute coronary syndrome: results of the OASIS registry 1 and 2. Indian Heart J. 2005 May-Jun;57(3):217-25  
12. Bhargava SK, Sachdev HS, Fall CH, Osmond C, Lakshmy R, Barker DJ, Biswas SK, Ramji S, Prabhakaran D, Reddy KS.  Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood. N Engl J Med. 2004 Feb 26; 350(9):865-75 .

 

 

 

 

 

 

 

 

Center Affiliations

Areas of Expertise

Other Areas of Expertise