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PHFI is helping to build institutional and systems capacity in India for strengthening education, training, research and policy development in the area of Public Health.
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Gagandeep K Walia PDF Print

Research Scientist and Assistant Professor.
Research Area:  Genetic and Epigenetic Epidemiology


gagandeepwaliaGagandeep Kaur Walia is a Biological Anthropologist by training and is working in the area of Genetic Epidemiology in Centre for Chronic Conditions and Injuries. She is skilled in genetic and epigenetic techniques and thus contributing in the area of genetic and epigenetic epidemiology in various grants. Her research interests include genetic and epigenetic determinants of cardio-metabolic traits and utilizing genetic information in examining causal inferences (Mendelian Randomization). She is interested in studying the genetic and epigenetic variants and their interaction with modifiable lifestyle and environmental risk factors to understand the etiology of chronic diseases, specifically cardiometabolic and respiratory disorders. She also manages the genetics laboratory of PHFI which handles DNA isolation from various biological sources, sample preparation for high throughput genotyping and epityping, systematic storage and bio-repository for different large scale projects

Recently she has been contributing in the Center for Environmental Health at PHFI and is involved with grants focused on air pollution and cardiometabolic health. Her research areas include indoor air pollution in environmental health and the utility of genetic and epigenetic mechanisms influencing air pollution and chronic conditions.

Currently, she has been awarded Wellcome Trust/DBT India Alliance early career fellowship to examine causal relationship between regional body fat distribution and lipid levels in Indian population using bi-directional mendelian randomization approach. The genome-wide resource that would be generated through this fellowship will address multiple research questions and will ensure long term research activities in genetic epidemiology of cardiometabolic traits

Publications

  • Saini S, Walia GK, Sachdeva MP, Gupta V. Genetics of obesity and its measures in India. Journal of Genetics (Accepted).
  • Gupta V, Somarajan BI, Walia GK, Kaur J, Kumar S, Gupta S, Chaurasia AK, Gupta D, Kaushik A, Mehta A, Gupta V, Sharma A. Role of CYP1B1, p.E229K and p.R368H mutations among 120 families with sporadic juvenile onset open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol. 2018. 256:355-362.
  • Oakley L, Baker C, Addanki S, Gupta V, Walia GK, Aggarwal A, Bhogadi S, Kulkarni B, Prabhakarn D, Ben-Shlomo Y, Smith GD, Radha Krishna KV, Kinra S. Is increasing urbanicity associated with changes in breastfeeding duration in rural India? An analysis from the Andhra Pradesh Children and Parents Study. BMJ Open. 2017. 7:e016331.
  • Gupta V, Walia GK, Sachdeva MP. Mendelian Randomization: an approach for exploring causal relations in epidemiology. Public Health. 2017. 145:113-119.
  • Matsuzaki M, Kulkarni B, Kuper H, Wells JC, Ploubidis GB, Prabhakaran P, Gupta V, Walia GK, Aggarwal A, Prabhakaran D, Davey Smith G, Radhakrishna KV, Ben-Shlomo Y, Kinra S. Association of hip bone mineral density and body composition in a rural Indian population: The Andhra Pradesh Children and Parents Study (APCAPS). Plos One. 2017. 12:e0167114.
  • Agrawal S, Walia GK, Staines-Urias E, Casas JP, Millett C. Prevalence and risk factors for eclampsia in pregnant women in India. Family Medicine and Community Health. 2017. 4:xx-xx. (In Press).
  • Shridhar K, Aggarwal A, Walia GK, Gulati S, Geetha AV, Prabhakaran D, Dhillon PK, Rajaraman P. Single nucleotide polymorphisms as markers of genetic susceptibility for oral pre-cancer risk: Review of evidence to date. Oral Oncology. 2016. 61:146-51.
  • Walia GK. Epigenetics as interplay between nutrition and cardiometabolic disorders. MFC Bulletin. 2016. May-July:1-5.
  • Shridhar K*, Walia GK*, Aggarwal A, Gulati S, Geetha AV, Prabhakaran D, Dhillon PK, Rajaraman P. DNA methylation markers for oral pre-cancer progression: a critical review. Oral Oncology. 2016. 53:1-9. [*Equal Contribution].
  • Walia GK, Vellakkal R, Gupta V. Chronic Obstructive Pulmonary Disease and its Non-Smoking Risk Factors in India. COPD: Journal of Chronic Obstructive Pulmonary Disease 2016. 13:251-261.
  • Gupta V, Millett C, Walia GK, Kinra S, Aggarwal A, Prabhakaran P, Bhogadi S, Kumar A, Gupta R, Prabhakaran D, Reddy KS, Smith GD, Ben-Shlomo Y, Krishna KV, Ebrahim. Socio-economic patterning of cardiometabolic risk factors in rural and peri-urban India: Andhra Pradesh children and parents study (APCAPS). Z Gesundh Wiss (J Pub Health). 2015. 23:129-136.
  • Matsuzaki M, Kuper H, Kulkarni B, Ploubidis GB, Wells JC, Radhakrishna KV, Prabhakaran P, Gupta V, Walia GK, Aggarwal A, Prabhakaran D, Rameshwar Sarma KV, Davey Smith G, Ben-Shlomo Y, Kinra S. Adolescent undernutrition and early adulthood bone mass in an urbanizing rural community in India. Archives of Osteoporosis. 2015. 10:232.
  • Walia GK, Saraswathy KN, Puri M, Shamshi MB, Dada R, Chahal SMS. Pro-inflammatory Cytokine Gene Polymorphisms and Recurrent pregnancy Loss in India. Molecular Biology Reports. 2015. (In Press).
  • Gupta V, Walia GK, Khadgawat R, Ng HKT, Sachdeva MP. Familial History: a strong risk factor of type 2 diabetes among the “Aggarwal” population of Delhi, India. International Journal of Diabetes in Developing Countries. 2015. 35:624-627
  • Walia GK, Gupta V, Aggarwal A, Md. Asghar, Sovio U, Kinra S, Timpson N, Smith GD, Dudbridge F, Prabhakaran D, Ben-Shlomo Y, Reddy KS, Chandak GR, Ebrahim S; the Indian Migration Study Group. Association of lipid traits with common genetic variants in Indian Population. PLoS One. 2014. 9:e101688.
  • Agrawal S, Walia GK. Prevalence and risk factors for symptoms suggestive of pre-eclampsia in Indian women. Journal of Women’s Health, Issues and Care. 2014. 3:6
  • Kinra S, Radha Krishna KV, Kuper H, Sarma KVR, Prabhakaran P, Gupta V, Walia GK, Bhogadi S, Kulkarni B, Kumar A, Aggarwal A, Gupta R, Prabhakaran D, Reddy KS, Smith GD, Ben-Shlomo Y, Ebrahim S. Cohort Profile: Andhra Pradesh Children and Parents Study (APCAPS). International Journal of Epidemiology. 2014. 43: 1417-1424.
  • Puri M, Kaur L, Walia GK, Mukhopadhyay R, Sachdeva MP, Trivedi SS, Ghosh PK, Saraswathy KN. MTHFR C677T polymorphism, folate, vitamin B12 and homocysteine in Recurrent Pregnancy Losses: A case control study among north Indian women. Journal of Perinatal Medicine. 2013. 41:549-54.
  • Elliott HR, Walia GK, Duggirala A, Groom A, Reddy U, Chandak, GR, Gupta V, Laasko M, Dekker JM, The RISC Consortium, Walker M, Ebrahim S, Smith GD, Relton CL. Migration and DNA methylation: A comparison of methylation patterns in type 2 diabetes susceptibility genes between Indians and Europeans. Journal of Diabetes Research and Clinical Metabolism. 2013. 2:6.
  • Molinari, F, Gupta, V, Prabhakaran, P, Meiburger, KM, Saba, L, Acharya, UR, Ledda, G, Krishna, KV, Walia GK, Kinra, S, Nicolaides, A, Ebrahim, S, Suri, JS. Automated IMT estimation and BMI correlation using a low-quality carotid ultrasound image database from India. Conf Proc IEEE Eng Med Biol Soc. 2013. 2013:3343-3346.
  • Gupta V, Khadgawat R, Ng HKT, Walia GK, Kalla L, Rao VR, Sachdeva MP. Association of TCF7L2 and ADIPOQ with BMI, WHR and Systolic Blood Pressure in an Endogamous Ethnic Group of India. Genetic Testing and Molecular Biomarkers. 2012. 16:948-951.
  • Sinha E, Walia GK, Gupta BP, Ghosh PK, Saraswathy KN. 2010. LDL-R AVA II and Nco I Polymorphism: An Indirect Risk Factor for Coronary Heart Disease among a Mendelian population of Delhi, India. Biochemical Genetics. 48:807-815.
  • Sinha E, Walia GK, Mukhopadhyay R, Samtani R, Gupta BP, Ghosh PK, Saraswathy KN. 2010. Methylenetetrahydrofolate reductase Polymorphism: An independent Risk Determinant of Coronary Heart Disease in an Endogamous Population from Delhi (India). E-SPEN, the European e-Journal of Clinical Nutrition and Metabolism. 5:e213-e218.
  • Saraswathy KN, Samtani R, Asghar M, Walia GK, Saxena R. 2009. Beta Thalassemia among the Sindhi Community in Delhi. National Medical Journal of India. 22:334-335.
  • Walia GK. 2008. Inherited Thrombophilia and Pregnancy Complications with Special Reference to MTHFR C677T Polymorphism. Research Proceedings in Anthropology. New Series:31-36.
  • 26Walia GK, Mukhopadhyay R, Saraswathy KN, Puri M and Chahal SMS. 2008. Immuno-Molecular Etiology of Recurrent Pregnancy Loss and the Anthropological Perspective. International Journal of Human Genetics. 8:227-235.
 
Last Modified : April 9, 2018, 11:38 am